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Currently, we cannot experimentally visualize, at atomic resolution, how the structures of biomolecules change dynamically over biologically relevant timescales. As a result, many aspects of biology and disease remain poorly understood. Our group is developing methods based on solution NMR spectroscopy and computational techniques that are yielding all-atom dynamical ensembles of nucleic acids in motion. These atomic "movies" not only help us understand processes such as HIV replication and DNA damage repair, they also provide the key for rationally designing therapies against diseases such as AIDS and cancer.