Currently, we cannot experimentally see biomolecules preforming their cellular functions – such as DNA replication and protein catalysis – at atomic resolution. Our group is developing methods that combine powerful Nuclear Magnetic Resonance (NMR) experiments with computational approaches – that make it possible to visualize the dynamics of biomolecules at atomic resolution. These atomic "movies" are allowing us to understand some of the most curious aspects of biomolecule behavior, such as how they change structure in a specific manner, make new discoveries that redefine the iconic DNA double helix, and also enabling biotechnological applications, such as RNA-targeted drug discovery.
02.2013 Hashim is the recipient of the 2013 Vilcek Prize for Creative Promise in Biomedical Science.
01.2013 Jeet, Katja, and Liz's paper is ranked top 10 by Faculty 1000 and #2 in Structural Biology!
11.2012 Former graduate student Evgenia Nikolova is the recipient of the Damon Runyon Cancer award.
09.2012 Jeet will start his independent position as Assistant Professor of Biology and Chemistry at the Indian Institute of Science Education and Research, Pune, India. Congrats Jeet!
09.2011 3D Maps of RNA Interhelical Junctions